Gene information
Official symbol FGF23
Official full name fibroblast growth factor 23
Gene type protein-coding gene
Chromosome12p13.32
Gene familyReceptor ligands; Fibroblast growth factor family
Resources
Entrez Gene 8074
HGNC HGNC:3680
Ensembl ENSG00000118972
Vega OTTHUMG00000168241
UCSC uc001qmq.1
GO terms: 70 records
GO Description Category LogP Number of genes Detail
GO:0001934 positive regulation of protein phosphorylation GO Biological Processes -52.8272623 84 More
GO:0005104 fibroblast growth factor receptor binding GO Molecular Functions -3.53254248 4 More
GO:0005788 endoplasmic reticulum lumen GO Cellular Components -47.2996164 57 More
GO:0005796 Golgi lumen GO Cellular Components -14.6918478 18 More
GO:0006766 vitamin metabolic process GO Biological Processes -3.00017540 12 More
GO:0006775 fat-soluble vitamin metabolic process GO Biological Processes -3.82142288 8 More
GO:0006873 cellular ion homeostasis GO Biological Processes -10.3574947 26 More
GO:0007167 enzyme-linked receptor protein signaling pathway GO Biological Processes -26.8285253 93 More
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway GO Biological Processes -16.7048742 60 More
GO:0007584 response to nutrient GO Biological Processes -29.4823239 48 More
GO:0008083 growth factor activity GO Molecular Functions -26.3260872 31 More
GO:0008543 fibroblast growth factor receptor signaling pathway GO Biological Processes -3.35297052 5 More
GO:0009725 response to hormone GO Biological Processes -49.1091700 138 More
GO:0009991 response to extracellular stimulus GO Biological Processes -42.2178323 102 More
GO:0010035 response to inorganic substance GO Biological Processes -29.1720710 89 More
GO:0010038 response to metal ion GO Biological Processes -20.5090881 61 More
GO:0019725 cellular homeostasis GO Biological Processes -21.1508273 85 More
GO:0030278 regulation of ossification GO Biological Processes -11.2759455 26 More
GO:0030279 negative regulation of ossification GO Biological Processes -7.69659659 12 More
GO:0030500 regulation of bone mineralization GO Biological Processes -10.1371537 13 More
GO:0030545 signaling receptor regulator activity GO Molecular Functions -87.4728446 102 More
GO:0030546 signaling receptor activator activity GO Molecular Functions -90.4065983 101 More
GO:0031667 response to nutrient levels GO Biological Processes -41.8130555 98 More
GO:0031668 cellular response to extracellular stimulus GO Biological Processes -10.2327580 36 More
GO:0031669 cellular response to nutrient levels GO Biological Processes -9.42886914 32 More
GO:0031670 cellular response to nutrient GO Biological Processes -9.31154255 13 More
GO:0032768 regulation of monooxygenase activity GO Biological Processes -14.2762890 21 More
GO:0032870 cellular response to hormone stimulus GO Biological Processes -24.7707938 79 More
GO:0033273 response to vitamin GO Biological Processes -22.1296854 31 More
GO:0033280 response to vitamin D GO Biological Processes -11.9382575 14 More
GO:0043269 regulation of ion transport GO Biological Processes -36.9814668 116 More
GO:0043408 regulation of MAPK cascade GO Biological Processes -57.2547066 142 More
GO:0043410 positive regulation of MAPK cascade GO Biological Processes -49.4744054 112 More
GO:0044070 regulation of anion transport GO Biological Processes -12.6410846 24 More
GO:0044321 response to leptin GO Biological Processes -5.08699974 5 More
GO:0044344 cellular response to fibroblast growth factor stimulus GO Biological Processes -7.12681878 10 More
GO:0045596 negative regulation of cell differentiation GO Biological Processes -26.9785067 101 More
GO:0045667 regulation of osteoblast differentiation GO Biological Processes -10.7517956 27 More
GO:0045668 negative regulation of osteoblast differentiation GO Biological Processes -3.60984508 9 More
GO:0048018 receptor ligand activity GO Molecular Functions -91.0736151 101 More
GO:0050801 ion homeostasis GO Biological Processes -12.0812968 60 More
GO:0051046 regulation of secretion GO Biological Processes -54.0079540 130 More
GO:0051048 negative regulation of secretion GO Biological Processes -20.2278199 42 More
GO:0051051 negative regulation of transport GO Biological Processes -46.8709407 107 More
GO:0051341 regulation of oxidoreductase activity GO Biological Processes -18.1249013 32 More
GO:0051353 positive regulation of oxidoreductase activity GO Biological Processes -12.6682372 20 More
GO:0055065 metal ion homeostasis GO Biological Processes -12.9426258 29 More
GO:0055074 calcium ion homeostasis GO Biological Processes -10.3600555 19 More
GO:0055080 cation homeostasis GO Biological Processes -11.5718912 30 More
GO:0055082 cellular chemical homeostasis GO Biological Processes -17.6289728 71 More
GO:0070167 regulation of biomineral tissue development GO Biological Processes -10.3239090 23 More
GO:0070371 ERK1 and ERK2 cascade GO Biological Processes -5.02945267 6 More
GO:0070372 regulation of ERK1 and ERK2 cascade GO Biological Processes -38.4320790 79 More
GO:0070374 positive regulation of ERK1 and ERK2 cascade GO Biological Processes -34.9831828 64 More
GO:0070741 response to interleukin-6 GO Biological Processes -9.27147512 9 More
GO:0070848 response to growth factor GO Biological Processes -40.6139195 102 More
GO:0070851 growth factor receptor binding GO Molecular Functions -16.9609899 22 More
GO:0071295 cellular response to vitamin GO Biological Processes -7.93931811 10 More
GO:0071305 cellular response to vitamin D GO Biological Processes -6.22004109 7 More
GO:0071345 cellular response to cytokine stimulus GO Biological Processes -39.647808 70 More
GO:0071354 cellular response to interleukin-6 GO Biological Processes -8.31494447 8 More
GO:0071363 cellular response to growth factor stimulus GO Biological Processes -39.8883675 98 More
GO:0071396 cellular response to lipid GO Biological Processes -37.0669488 98 More
GO:0071496 cellular response to external stimulus GO Biological Processes -17.0078490 52 More
GO:0071774 response to fibroblast growth factor GO Biological Processes -7.87961599 11 More
GO:0072507 divalent inorganic cation homeostasis GO Biological Processes -10.6286093 21 More
GO:0098771 inorganic ion homeostasis GO Biological Processes -12.1048319 31 More
GO:0110149 regulation of biomineralization GO Biological Processes -10.9748263 24 More
GO:1903530 regulation of secretion by cell GO Biological Processes -45.6472055 114 More
GO:1903531 negative regulation of secretion by cell GO Biological Processes -17.4034654 36 More
KEGG pathways: 11 records
KEGG Description Category LogP Number of genes Detail
hsa04010 MAPK signaling pathway KEGG Pathway -13.6331973 26 More
hsa04014 Ras signaling pathway KEGG Pathway -9.01898803 33 More
hsa04015 Rap1 signaling pathway KEGG Pathway -8.52596130 17 More
hsa04020 Calcium signaling pathway KEGG Pathway -10.4415222 36 More
hsa04151 PI3K-Akt signaling pathway KEGG Pathway -29.3006421 73 More
hsa04810 Regulation of actin cytoskeleton KEGG Pathway -10.0068804 19 More
hsa04928 Parathyroid hormone synthesis, secretion and action KEGG Pathway -3.30201840 7 More
hsa05200 Pathways in cancer KEGG Pathway -30.6393212 92 More
hsa05218 Melanoma KEGG Pathway -5.33688125 8 More
hsa05224 Breast cancer KEGG Pathway -6.01672252 21 More
hsa05226 Gastric cancer KEGG Pathway -5.33653529 20 More
Drug-Gene interaction
view
Related drugs: 1 record
Drug name Interaction type Source PMID View
burosumab antagonistinhibitor ChemblInteractionsTTD 2954567016690967 view
Related studies: 5 records
Molecular factor Omics type Application Objective MI type Reference
fibroblast growth factor 23 proteomics myocardial infarction[diagnosis] myocardial infarction di Giuseppe R et al. Eur J Epidemiol. 2015
fibroblast growth factor 23 proteomics death[prognosis (bad)] acute myocardial infarction Fuernau G et al. Crit Care. 2014
fibroblast growth factor 23 proteomics death[prognosis (bad)] acute myocardial infarction Fuernau G et al. Crit Care. 2014
fibroblast growth factor 23 proteomics left ventricular remodeling[prognosis (bad)] acute ST elevation myocardial infarction Reindl M et al. Heart. 2017
fibroblast growth factor 23 proteomics left ventricular ejection fraction[other] acute myocardial infarction Takahashi H et al. Circ J. 2018
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